Would assume that Moreno, Lallana, Keita, Shaqiri, Sturridge and Origi are nailed on to start. Timing of the Clyne deal seems strange, other than the Warnock fume, in this context as he'd have definitely got a game here. Maybe being cup tied had a part to play.
Like other have said, the midfielders and strikers in the above list seem pretty perfectly suited to a 442 diamond, so expect that with Henderson asked to go again as DM. No clue what we do across the rest of the defence.
Hope we win this, still have a lot of time for the FA Cup. Right to treat it as our third priority though.