Aguero's absence is the one that really hurts them.
He was insanely good in their winning run last year.
When you suddenly no longer can bank on a goal machine every game then either one of your other players has to step up (Jesus, Sterling, KDB) with a goal or two OR you have to ensure you don't let in anything at the other end.
In this match, Jesus missed a relatively straightforward header, and a few half chances were missed, a few runs never made into the right areas ... small margins.
Laporte, Aguero, both missing = a little less sharp at both ends of the pitch, and when the match is on a razor's edge, sometimes they lose