2,7 offsuite for me.
No chance of flush or straight, and a pair of two's or sevens most likely won't win you the pot.
The hand I hate to play though(as I never play 2,7 offsuite) is J,K, I always lose with that hand, I only play that hand now if I got the button, or if they are suited and I can see a cheap flop.
For me it is any hand you choose not to fold and end up losing. that included having pocket a pocket pair that turns into a full house. Especially if you pocket pair gives you the under hand, for example you may have a pair of pair of tens, on the flop you could get 10 K K. you have a full house 10's over K's. You read the other player you then play and lose because he has K 10 pocket cards.
Online you can't read a player, so it is hard to tell if you could lose a full house to a better over hand. Live however you really can tell that they may be holding a better Fullhouse.
It is also about how you play, slow play, quick raising, check raising.
a 2 7 offsuit i love, because it is decision made, you fold, job done (unless in a position to be forced all in) I particulary hate holding middle pairs offsuit picture cards, (10 Q) (9 J suited) anything like that as they are so tempting to bet big with.
One thing I have learnt is that you should never be afraid to fold and fight again (even if you are fairly confident of the win) only go if you are nearly 100% that you will beat the personm you are in the hand with.
Also play the chips, if you have something decent dealt to you, and you can force the short stack all in, lose the hand and still be in the top two stacks, then it is worth a play. This all depends on table position aswell, I personally will not call someone all in if there is a chance that another player can call it aswell. Ideally if you are on the large blind and everyone else has folded apart from the short stack, that is the best time to attempt to bring someone all in (worst out come is you lose but remain well stacked, you may only win the blinds because the short stack folds, however you could win and send someone out) The othwer time to do this is by being the first person to act (this could be 1st person after the BB, or maybe even further on the table if other fold before your turn) make a small raise to test the water, if all fold apart from the short stack you can try and bring them all in.
You really never want to attempt to bring a short stack all in with a 3rd or 4th person in the action, as you could lose bigger and alllow the Short stack to treble or quadruble through, allow a new chip leader and leave yourself in a worse position.