Here’s a question. There are a lot of “experts” out there talking about tired players based on minutes played across the season... but if you have three games with ten days between them or so, does that length of recovery effectively reset the healing-based clock?
Yes and no.
So this study
here shows that you have an increased risk of getting an injury if your games were less than or equal to 4 days apart come to more than or equal to 6 days, which is why our Christmas break was pretty much perfect with the majority of games being 5 days apart and allowing for optimal rest and recovery. You could theorise that having 10 days between games would reduce the injury risk further however this study
here shows that players with a higher workload are actually protected against injury than those with lower workloads. Essentially if you play a match every 10 days then you won't be conditioned for the high workload and intensity of a match day which would also lead to an increased injury risk. The sweetspot is between 5 and 7 days rest between matches, but to throw a curve ball in there
this study shows that if your players are used to playing matches every 4 or 5 days then the risk of injury is also reduced, it's how you deal with the between game days rather than giving the players a complete rest and Champions League clubs generally fair better during busy periods than those who don't play midweek most weeks.