The selection makes sense to me - this is not about not playing your strongest 11, it's about playing your freshest 11. And only Klopp and the coaching staff have the information.
Thankfully, the drop off is not that large and there is still the option to bring them all from the bench. To be the honest, the area that most concerns with the changes is Jones not playing in the midfield. He has been critical in keeping us compact and not leaving Mac all by himself in defending transitions. Grav and Elliot are both much more attacking than Jones.
So midfield is more of a concern for me even though you'd rightly argue that Quansah for Konate is a bigger drop off.
In any case, I don't think the drop off is that much and if we play as well as we can, we should be beating Fulham. Up the Reds!