The World Health Organization said Friday that the original epicentre in China of the coronavirus outbreak at last reporting no new cases gave hope to the rest of the world battling the pandemic.
The city of Wuhan registered no new cases of Covid-19 in 24 hours - for the first time since reporting its first case in December in an outbreak that has gone on to infect more than 250,000 people around the world and kill more than 11,000 people.
"Yesterday, Wuhan reported no new cases for the first time since the outbreak started," WHO chief Tedros Adhanom Ghebreyesus told a virtual news conference in Geneva.
"Wuhan provides hope for the rest of the world that even the most severe situation can be turned around.
"Of course, we must exercise caution; the situation can reverse. But the experience of cities and countries that have pushed back this coronavirus gives hope and courage to the rest of the world."
China as a whole is now reporting only a handful of new infections each day - all of them apparently from overseas visitors - as the crisis has shifted from Asia to Europe, which has now reported more deaths than China.
Dr Tedros said the WHO's greatest worry was the impact that the virus could have if it took hold in countries with weaker health systems or more vulnerable populations.
"That concern has now become very real and urgent," he said, but added that significant sickness and loss of life in such countries was not inevitable.
"Unlike any pandemic in history, we have the power to change the way this goes," he said.
The Chinese National Health Commission reported just three new fatalities, the lowest daily increase since it started publishing figures in January.
There have been nearly 81,000 infections in China, but fewer than 7,000 people remain sick with Covid-19 disease.
The virus is believed to have emerged in an animal market in the central city of Wuhan in December.
Some 56 million people in Wuhan and the surrounding Hubei province were locked down in late January, but authorities are progressively easing the travel curbs as cases have dwindled.