I've lived in the city my whole life and it's interesting to get an outsider's view of New York. I'm guessing New York is a popular spot for you all!
For those wanting to visit, are about to visit or just simply curious --
Manhattan is great, but there's a growing outer borough culture where hip and trendy bars are popping up. Brooklyn (where I live) has some great spots, especially close to the City (what us NY'ers call Manhattan...it's confusing, I know.) Brooklyn Heights is really scenic, especially at night. There's this one spot called the Promenade --
http://cache.virtualtourist.com/1872979-Brooklyn_Heights_Promenade-Brooklyn_Heights.jpg. It's wonderful, scenic spot and a good photo opportunity.
Queens is also a hidden gem and as mentioned before, Astoria is where it's at. Also, a lot of people don't know this, but there's ANOTHER Chinatown in the city -- actually, three of them. This one in Flushing is massive and there are so many great restaurants to choose from, you can't go wrong. A bit out of the way from the hussle and bustle of Manhattan, but worth the trip.
I used to work in the Chelsea area of Manhattan and there's one place -- Chelsea Market -- that has a lot of good food. It's also where the Food Network is headquarters and that guy Iron Chef Morimoto has his steakhouse. Also has free dance classes on certain days and other stuff like brain teasers and quizzes.
The great thing about New York is that you can literally walk down one block and find something completely new and exciting. It's an exciting city to live and work in, although the weather has been piss poor the last week or so.