I see a few choices to be made with the team selection.
First choice is Matip or Konate? I can argue the toss either way. Matip is more seasoned so he will probably get the nod. But if the game is physical, Konate might have a bit more about him in that regard. Tough decision.
Second choice is what midfielder plays with Fabinho and Henderson. Assuming no injury niggles that pairing has to start. Then after that, what do you do? Thiago has shown his class lately, and in a footballing contest, he would help us dominate the Ev. But will it be a footballing contest? Thiago's slight weakness, for the mad dash that is sometimes Premier League football, is that he can get hustled out of his stride. It's not hard to imagine him getting his pocket picked, or even fouled, the foul not given, and then Everton taking advantage. I would probably play Ox instead, but I'm not fully sure. The main thing is that Fabinho and Henderson have to be in the midfield.
Up front there's another choice to be made. Origi has a decent record against Everton, and in the cameo appearances we have seen lately he did look hungry. If he plays, who will make way? Jurgen gives Mo a rest about this time. Or maybe Jota will be rested, as we will be depending on him more once AFCON comes around?
I will be happy if Matip, Thiago and the main three strikers all play, but I think we could see some changes.