Don't know what to make of Southampton. I thought a full season under Hassenhuttl would see them join the likes of Leicester and Wolves as a Top 10 team and a Europa League pretender. At the very least, they should be the "best of the rest" if you exclude the usual Top 6, Leicester, Wolves, Everton and potentially West Ham. But their performance at Burnley was horrendous, and I now wonder if Hassenhuttl will actually be able to reverse the damage done by Pellegrino and Hughes.
As for us, I'm not actually overly worried about our exerts in Istanbul. We've got the fittest squad in the Prem, and I would expect us to be able to overcome our exhaustion, especially with a more reasonable temperature. I can see Origi playing on the left since Mane has only just returned. My rogue shout is that we'll see Fabinho rested and Lallana having a go at the #6 role for the first time.