In it's early days Friends reached heights that very few sitcoms ever do, only try-hard snobs will dispute that. The character of Chandler was my personal highlight of a show that never missed a beat back then. He was the perfect mix of quick wit, sarcasm and pathos.
As others have said, it's one of those deaths that has hit me more than expected. Those six have always just been there haven't they? It doesn't seem right that one of them is gone.