I think what the Pope has said demonstrates the difference between being disrespectful on a personal level, to a particular person, and being disrespectful in a more general way, in the media, in the name of satire. If a person deliberately insults you or makes offensive comments about your family, or something similar that is very important to you (for example, making a joke about Hillsborough), they would expect a hostile response. Obviously responding violently would be against the law and should be, but being deliberately offensive on a personal level without provocation is, quite rightly, frowned upon in our society.
I also think there is a risk that encouraging a culture of 'disrespect' can just give the green light to people who are ignorant or motivated by hate to be as offensive as they like, and just claim that it's 'satire'. When we talk about the idea of being 'disrespectful' in relation to satire, what we really mean is being irreverent - but I think some people will just use it as an excuse to be ignorant, and deliberately offensive - but not to make a satirical point, just out of hatred.
At school my daughter is taught about other religions and their beliefs / customs, I expect her to grow up respecting those in the sense that she doesn't ridicule or look down on them, just out of basic human decency. It doesn't mean she believes in them herself, and when she's old enough she'll be free to analyse and criticise them if she wants to.