Author Topic: New Research into Autism - any more info?  (Read 1479 times)

Offline Elli

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New Research into Autism - any more info?
« on: December 5, 2005, 07:31:43 pm »
Just read the following article in the Guardian - the research sounds relatively solid from the article, it's an area that really interests me and I wondered if anyone had any more (access to) information about it. I've had a look on the NAS website but not turned much up yet. Currently chatting about it to a good mate whose older brother is severely autistic - my mate works for social services in the Durham and Bolton areas and has had some fascinating stuff to tell me - any RAWKites in a similar position or with any views about it?




Scans of autistic children show faults in brain circuits

Ian Sample
Science correspondent

Brain scans of autistic children have revealed striking faults in key brain circuits that could explain the range of social difficulties such youngsters experience, neuroscientists claimed yesterday.

Detailed snapshots of the children's brains showed that networks of nerves thought crucial for understanding other people's emotions and intentions did not spark into life at the appropriate moment. The more severe a child's autism, the less activity the circuits showed.

In the study, neuroscientists led by Mirella Dapretto, a psychiatrist and brain mapping specialist at the University of California in Los Angeles, showed a series of faces to two groups of children with an average age of just over 12 years. The children in one group had been diagnosed with autism; the others showed no signs of the disorder.

Every child tested saw 80 faces, each of which expressed either anger, fear, happiness, sadness or a natural state. In separate scans, the children were asked to observe the face or imitate the expression.

The researchers found a striking difference between the brain scans of the two groups of surveyed children. When the non-autistic children saw the faces, vari¬ ous parts of their brains flickered into life, including clumps of nerves called mirror neurons. This group of nerves is thought to play a key role in helping us understand how others are feeling, for example by mirroring in ourselves feelings of sadness if we see someone looking miserable.

Significantly, brain scans showed that when autistic children looked at the faces, they processed the features properly, but the mirror neurons conveying the emotion of the expression failed to light up.

In the next test, children were asked to imitate the expression on each face flashed up before them. Again, the scans showed that clumps of mirror neurons burst into life in children with normally developed brains. When autistic children mimicked the expressions, they hardly flickered at all. The scans suggest that while people with autism can recognise expressions, the brain circuits that attach emotion to them are faulty, making it hard or impossible to read others' feelings.

The study, which was published in Nature Neuroscience yesterday, shows that the problem lies with a particular region of the brain known as the pars opercularis, which is rich in mirror neurons. In a final set of scans, the scientists showed that increasingly severe autism went hand in hand with rapidly decreasing activity of the mirror neurons.

"This mirroring mechanism may underlie the remarkable ability to read others' emotional states from a mere glance," said Dr Dapretto. "Our findings suggest that a dysfunctional mirror neuron system may underlie the social deficits observed in autism. This is exciting because we finally have an account that can explain all core symptoms of this disorder."

The Guardian

Offline Aidan_B

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Re: New Research into Autism - any more info?
« Reply #1 on: December 5, 2005, 08:34:29 pm »
The research seems, from a very curse reading, to be sound.  The problem would be in the next stage of being able to do something about it.  It is a very large leap from knowing what is causing a disease/disorder/illness to be able to treat it.  But try the links below because they know a lot more than I do.


This link might work to the original paper:
http://www.nature.com/nrn/journal/v6/n1/pdf/nrn1598.pdf

If not, I can email you the .pdf of the nature review.

The original paper is

Vargas D. L. et al  Neurological activation and neuroinflammation in the brain of patients with autism Annals. Neurol., 15th November 2004 (10.1002/ana.20315)

and the webbie of the research group is http://www.neuro.jhmi.edu/neuroimmunopath/autism.htm

Offline Elli

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Re: New Research into Autism - any more info?
« Reply #2 on: December 5, 2005, 09:15:38 pm »
Superb, thanks mate. Totally sidetracked by the articles on dreams and schizophrenia now...

Will have to borrow a medical dictionary over Christmas! ;D

Offline Aidan_B

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Re: New Research into Autism - any more info?
« Reply #3 on: December 5, 2005, 10:35:44 pm »
No worries kellyi.

All I know about Autism is from Dustin Hoffman anyway.

Offline Barney_Rubble

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Re: New Research into Autism - any more info?
« Reply #4 on: December 13, 2005, 01:18:32 pm »

Elli do you get the BBC where you are?

Tonight on BBC2 at 9.00 - Magnificent 7

Helena Bonham-Carter stars in this tough, rewarding drama - inspired by Jacqui Jackson's experiences in the documentary My Family and Autism - which charts the laughter and heartbreak of a family over 12 months. Maggi has seven children - four of whom are autistic. Curtis is terrified of red and has myriad allergies; Christopher takes everything literally; Richard hates surprises and Davey has attention deficit hyperactivity disorder. Life is never dreary at the Jackson's. My Family and Autism is reshowing on BBC4 at 10.25pm.

87:13

Offline Elli

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Re: New Research into Autism - any more info?
« Reply #5 on: December 13, 2005, 05:43:14 pm »
Elli do you get the BBC where you are?

No, but they get it in Worsley and I just made a timely phone call - thanks a lot for that tip-off, I'll hopefully be able to watch the tape on Saturday :)

Offline Barney_Rubble

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Re: New Research into Autism - any more info?
« Reply #6 on: December 13, 2005, 05:47:55 pm »

No, but they get it in Worsley

Since when?? :o  ;D

87:13

Offline Consigliere

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Re: New Research into Autism - any more info?
« Reply #7 on: December 14, 2005, 11:20:37 am »
..and don't forget the brilliant book, "Curious Incident of the Dog in the Night Time"
http://mostlyfiction.com/contemp/haddon.htm

Offline Elli

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Offline Elli

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Re: New Research into Autism - any more info?
« Reply #9 on: January 10, 2006, 05:37:33 pm »
In the unlikely event that this will interest anyone who hasn't already seen it, there's a page on the National Autistic Society's website with links to 2 WMP streams - the first is about a school in Nottingham and the second is about the Jackson family.

Enjoy :) http://www.nas.org.uk/nas/jsp/polopoly.jsp?d=161&a=7808

Offline the invisible man

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Re: New Research into Autism - any more info?
« Reply #10 on: January 13, 2006, 09:38:13 am »
 :wave

Ellie,

How are you?

I am a Special Needs Teacher from Queensland Australia.

I teach kids with Autism and Down Syndrome etc.

Do you have a child with Autism?

Drop me a line if you would like some current info...

TIM... 8)
t.i.m...

Offline Elli

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Re: New Research into Autism - any more info?
« Reply #11 on: January 13, 2006, 03:49:31 pm »
Conversation was continued via IM, thanks Garreth.

Offline Elli

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Re: New Research into Autism - any more info?
« Reply #12 on: March 8, 2006, 11:56:23 am »
Just found an article from the Telegraph in with a letter from my Aunt, there's no date on it but it must be in the last few days of February.


A meeting of minds that may lead to Autism
Roger Highfield

The recent rise in autism may have been driven by the tendency of like-minded engineers, physicists, mathematicians and other "systemizers" to marry each other, according to a Cambridge University professor.

Around one child in every 100 - mostly males - has autism and the number of cases seems to be on the increase, though some argue that it is due to greater awareness and changes in diagnosis.

In a new study, Prof Simon Baron-Cohen believes the impaired ability of people with autism to communicate, recognise emotions and socialise is linked with the same genes that enable a person to systemize - find the laws that govern how a system works.
This is more often a male trait and present among scientists.

He has uncovered clues that suggest that when systemizers marry they have a higher risk of having children with autism. And he believes that systemizers are also more attracted to each other than one would expect by chance, due to what he calls "assortative mating".

Systemizers feel more comfortable in the company of each other rather than that of what he calls empathizers. "We have found clues in a range of studies we have conducted since 1997 that assortative mating is going on".

In the journal Archives of Diseases of Childhood this month, Prof Baron-Cohen reports various suggestive clues to link systemizing with autism. According to a survey of 1000 members of the National Autistic Society, fathers and grandfathers of children with autistic spectrum conditions are twice as likely to work in systemizing professions such as engineering.

Empathizers
- Tend to be female.
- Show the drive to identify another person's emotions and thoughts, and to respond to them with an appropriate emotion.
- Empathizers intuitively figure out how people are feeling, and how to treat people with care and sensitivity.
- Not preoccupied with patterns or repetitive events. Relaxed about details.
- Develop language rapidly. Sociable and communicative.

Systemizers
- Tend to be male.
- Possess a drive to analyse and explore a system - such as a vehicle, a computer, a maths equation, or even an army unit - to extract underlying rules that govern a system's behaviour; and the drive to construct systems.
- Intuitively figure out how things work, or what the underlying rules are.
- Repetitive behaviour, preoccupation with arranging things, obsession with detail.
- Less interested in chatting. Less sociable.

Students in the natural sciences have a higher number of relatives with autism then do students in the humanities, and mathematicians have a higher rate of autistic spectrum conditions compared with the general population.

The theory that both parents of children with autism are strong systemizers is also evident from a study that shows both mothers and fathers score above average on a questionnaire that measures autistic traits.

The parents are also faster at "visual search tasks" - in effect they have an unusually sharp eye for detail, just as their child with autism does - compared with the parents of unaffected children.

Brain scan studies of mothers and fathers of children with autism have shown that the mothers have a masculinised pattern of brain activity, again suggesting they are strong systemizers.

When all the evidence is taken together it suggests a genetic cause of autism, with both parents contributing genes that ultimately relate to a similar kind of mind: one with an affinity for thinking systematically.

Prof Baron-Cohen says the rise in autism could be driven because assortative mating is becoming easier: recent years have seen a rise in mobility, an increase in the employment prospects of systemizers - notably in the computers industry - and a rise in the numbers of women studying mathematics, engineering and other systemizing subjects at university, where they are more likely to come into contact with systemizing men.

He points out that the parents of children with autism may not have strong skills in such subjects, but that does not mean they are not strong systemizers.

The parents for example may have a remarkable memory for the names of songs in their CD collection, or for dates or telephone numbers.

He thinks the key characteristic is "exactness" in their style of thinking.

In the spectrum of conditions that count as autism, the largest groups are classic autism and Asperger syndrome. Both share features: a difficulty in developing social relationships, a difficulty in communication, the presence of unusually strong, narrow interests, and a strong adherence to routines.

They differ in that in classic autism, the person might have an IQ at any point on the scale, even in the learning disabled range, and the person invariably had a language delay as a toddler.

In Asperger syndrome, the person is always at least average in IQ, and may be well above average, and talked on time as a toddler.

rhighfield@telegraph.co.uk




I'd be really interested to hear what people think about this article. My initial reaction is serious wariness, especially about his conclusion that it must be a genetic inheritance. Also, the last couple of paragraphs appear to be spun out just to make up the copy word requirement, which is a shame.

« Last Edit: March 8, 2006, 11:58:03 am by Elli »

Offline Vinay

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Re: New Research into Autism - any more info?
« Reply #13 on: March 13, 2006, 03:58:28 pm »
So Rafael Benitez is a Systemizer.
« Last Edit: March 14, 2006, 05:14:23 pm by Vinay »

Offline Elli

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Re: New Research into Autism - any more info?
« Reply #14 on: March 14, 2006, 01:15:17 pm »
I've since read another Roger Highfield article, also cut from the Telegraph and sent to me, this time about 4 year old twins who still speak their own private code rather than English. It was similarly vacuous and felt very ill-founded, and surely a Science Editor should be doing better.

Seems to me Baron-Cohen is talking a load of generalised word-coinage bollocks and Highfield finds it very easy to satisfy his copy requirements with minimum effort on his part.

For a start, how many people fall either into the category of Empathiser or that of Sympathiser? I know I don't...