Crossing fingers everyone came through the weekend unscathed enough to be in consideration, and Virgil looks less "like shit", I'd be hoping for something like this
Kelleher
Trent Quansah VVD Gomez
Elliot Mac Jones
Jota Gakpo Diaz
I'd start Elliot over Grav, but since he played 75 minutes I could see Grav come in (likewise for Jones).
Since Jones covered the deepest role when Mac had to go off, there's a chance he's saved for the second half (with Grav starting fresh)
I''d also be happy enough with Bradley or Beck/Chambers coming in for one of the fullbacks - Trent and Gomez are the two I'm most concerned about coming through the game.
Because Jota and Mac will have their minutes managed, you'd guess Jota goes off for Nunez and Mac goes off for Grav (if it's the first mid sub).
Then you'd think Clark/McConnell and Bradley (or other fb) would be the third and fourth subs.
Fifth sub if it happens could be Konate for dealing with long balls, Nyoni for a cameo (would it break any record?), or whichever other young player wasnt already brought on.