For those who want regulars nowhere near this line up, what would your teams be?
For me I think a team something like the below would be reasonable
Kelleher
Williams
Konate
Phillips
Tsimikas
Morton
Thiago
Milner
Minamino
Origi
Mane/Salah/Jota
The above gives a fair amount of rotation and allows Alisson, VvD, Matip, TAA, Robertson, Fabinho, Henderson, AoC and 2 of Mane/Salah/Jota to get some rest (i.e. not start the game). I think there's some justification to play Thiago and get 60-70 mins under his belt. He's hardly played so getting game time might do him good. I think Henderson/Robertson could do last 20-30 mins to keep them ticking over. I think AoC deserves to start against Southampton so I'd use him off the bench to rotate either Milner or the one 1st choice forward who starts.
In the starting XI I wouldn't expect Thiago, Tsimikas, Milner and Salah/Jota/Mane to complete 90 minutes. I think we'll use the 5 subs and the bench will primarily be the 1st team players not starting and maybe the odd under 23 player.
We might get injuries with the above team. That's always a risk to some degree. But we'd be taking most of the key players out of the firing line. I think the above team (or something similar) strikes the balance between trying to win (money and sporting integrity wise) and protecting key players. Playing an U23 team is not realistic IMO.