Has to be fender, amps wise for me. My mates fender twin is late 60s and sounds superb. Use pedals for gain channel anyway, so for me it's all about that fender clean tone and then rat or other overdrive for louder stuff, which is pretty rare these days, mainly just use tuner tremolo and delay pedals wise now.
I'm also left handed tony, pain isn't it. I've got 2 electrics, an epiphone casino which is great sounding despite the pickups being rusty as hell, although the g string on epiphones never seems to stay in tune, had other guitars by them in the past and same problem. My main guitar is a reverend jet stream which is kind of a jaguar inspired shape but without the mad loads of controls. Lovely guitar, excellent brand if you come across one and they did tons of left handed models.
I'm also lucky in that a band I play drums in has a left handed guitarist with a lovely fender strat , and the other band I drum for has a left handed bass player so I get to try other stuff too which is brilliant.