Last time the lineups were:
Hart
Zabaleta Kompany Lescott Kolarov
Fernandinho
Toure Silva
Navas Nasri
Negredo
Mignolet
Johnson Skrtel Sakho Cissokho
Lucas
Allen Henderson
Sterling Coutinho
Suarez
I thought we dominated the midfield quite well with that lineup. What changes now though is that we'll be playing with another striker. I would think we'll be looking to play 433, otherwise we could leave a lot of space on the wings for their fullbacks and Navas to exploit. My guess is that we'll try to contain David Silva and Toure as a unit by limiting their space rather than do anything special like man-marking him.
I'm expecting the Arsenal/Everton/Spurs treatment: an aggressive press in a medium block, keeping our midfield and defense close together to close the space between them for their midfielders to roam. That sort or tight energetic game suits us more than them, as they like to move around the pitch at their own slow almost-laboured pace. Coutinho is really suited to that style as he's great at making those runs forward and threading the through-ball so I'd expect him to play, especially as its a home game where he usually excels. I wouldn't be at all surprised to see Allen playing though to help out defensively a bit more.
My choice would be our optimal Blitzkrieg lineup:
Mignolet
Johnson Skrtel Agger(if fit) Flanagan
Gerrard
Sterling Coutinho Henderson Suarez
Sturridge
Keep the two rows compact and hit them on the break at pace.