Maybe, but we could guarantee top four this week if we beat West Brom and Stoke. That would give us Chelsea and Brighton to build up any fitness if we hopefully need them in the CL final we are obviously making.
Of course there is the risk that they could get injured tomorrow and we need these fringe players against Roma. But I would not be keen for us to be needing to go to both Chelsea and Brighton needing something to get top four.
This is where the expression hope for the best, plan for the worst comes in.
What if you go full strength and get injuries. You then have squad players who aren't match fit who are off the pace in the key CL semi's or against Chelsea. What if you go full strength and lose points anyway, when do you give the fringe players minutes then?
Given recent injuries to Lovren, Robertson and the work load of Firmino & Trent in recent games, that is arguable as full strength as you can go without taking unnecessary risks in terms of players we may be needing a rest to properly get over little knocks or prevent accumulative fatigue getting into dangerous levels.
The question is would you rather that lineup faces West Brom or Roma?