I'd also start Grujic. We bought him for a reason and with 2 midfielders out it would make sense to play him. I think he would be well up for a derby. Another option, like others have said, is to put Coutinho there. That really depends on how he comes back from that long trip (as well as Firmino). Grujic, Can and Gini and midfield with the usual 3 up front. If no more injuries occur. Both sides will be missing players and after an international break I don't think we'll see any semblance of our usual rhythm, or theirs. It will probably be a really scrappy game with 1 goal winning it.