It's a well known fact that Shankly used just 14 players during the whole of the 65/66 campaign which saw us win the First Division and reach the European Cup Winners’ Cup final. In comparison, and very much enforced, Klopp has used (if I'm correct) 16 players to cover just the back 5 positions so far this season!
Keepers: Alisson, Adrian, Kelleher
Left back: Robertson, Tsimikas
Right back: Trent, N. Williams, Milner
Centre back (quicker to list those that haven't played, but): VVD, Gomez, Matip, R. Williams, Phillips, Fabinho, Henderson, Koumetio
Other than Koumetio's league cup appearance, all have been in important Prem or Champions League games.
And it's likely (hopefully) going to increase in the coming weeks!