Whilst all the whispers coming from WB/DC appear to lead to more stand alone movies instead of a shared universe, I don't think they should quite give up on the Justice League quite yet.
Wonder Woman and Aquaman (now DC's biggest film ever) have been huge hits for the DCEU and would form a solid base going forward. Brushing 4 films completely under the carpet (MoS, BvS, SS and JL) would be admitting monumental failure. The easiest and most logical way of approaching this problem, with Affleck gone and Cavill seemingly the same, is a version of Flashpoint. A Flashpoint film would give them a way of conveniently erasing the shit stuff whilst keeping the good stuff. The Flash would be the only character who knew the old Batman and Superman so could reference them to include them in the Universe loosely but going forward they wouldn't exist.
DC can still develop standalones like the upcoming Joker film but this would also be going on