Robinho, who started Brazil's win over Japan, has been ruled out with a minor thigh muscle injury, so Adriano is likely to return to the side.
Alternatively, Ronaldinho could move up front with Juninho coming into midfield but coach Carlos Alberto Parreira will delay making a decision until Tuesday.
Ghana's influential midfielder Michael Essien is suspended for the match.
Razak Pimpong hopes to be fit after injuring a rib against the USA, but otherwise Ghana are at full strength.
Robinho, who suffered the injury to his right thigh in training on Sunday, says he hopes to be fit for next Saturday's quarter-final, should Brazil reach that stage.
With qualification assured after the first two group games, he was one of five changes made to the team for the 4-1 win over Japan.
But that is just part of coach Parreira's approach of having no-one in the squad whom he regards as being a reserve.
"Whatever team plays we will be well represented," he said.
"Our objective is to win the World Cup. I have 23 solutions and I don't have any problems."
Probable teams
Brazil: Dida; Cafu, Lucio, Juan, Roberto Carlos; Gilberto Silva, Juninho Pernambucano, Kaka, Ronaldinho; Ronaldo, Adriano.
Ghana: Richard Kingston; John Paintsil, Habib Mohammed, John Mensah, Shilla Illiasu; Derek Boateng, Stephen Appiah, Otto Addo, Sulley Muntari; Matthew Amoah, Asamoah Gyan.
Referee: Lubos Michel (Slovakia).
Spain coach Luis Aragones has included Arsenal's Cesc Fabregas and Raul in the starting XI after resting many first choice players for the last group game.
Raul should come in at the expense of forward Luis Garcia, and Fabregas will replace midfielder Marcos Senna.
French coach Raymond Domench has Eric Abidal and Zinedine Zidane back after bans so his only worry is whether to play Thierry Henry alone up front.
He will leave it late before deciding if David Trezeguet will partner him.
Probable teams
Spain: Casillas, Sergio Ramos, Puyol, Pablo, Pernia, Xavi, Alonso, Fabregas, Raul, Torres, Villa.
France: Barthez, Gallas, Abidal, Thuram, Sagnol, Malouda, Makelele, Vieira, Zidane, Ribery, Henry.