It depends on the pitcher, the situation in the game and, to an extent, the time in the season, but I'd say most starting pitchers will throw somewhere between 90-110 pitches. Some will throw more; Justin Verlander tossed 130-odd recently, but that's a real exception. Leave a pitcher in too long and a) he'll be more likely to hurt himself and b) his command and velocity will suffer.
Yeah, early in the season, you won't see too many pitchers unless they are in the Verlander category being asked to throw more than 100+ pitches, as they've yet to build up endurance and arm strength. Basically you want your starter to at least try to aim for five innings or more of work, as it puts less of a strain on your everyday relief pitchers, who may be asked to work two days in a row and lack the endurance and technical ability to work more than an inning or two at a time. In the early days of baseball up until the 1970s, most starting pitchers threw complete games and limited rest, but many were absolutely wrecked by the time they were done, or in the case of the great left-handed pitcher Sandy Koufax ended up calling it a day far earlier than they may have done in the contemporary era in order to prevent permanent damage to their arms and hands.
We're beating up the Twins and the White Sox. I'll give it a while yet before I'm celebrating.
Yeah figured you'd do well against these two teams
Can't see him be sacked yet, even if he's clearly out of his depth. He'll be on a shorter leash though. You have an easier run of games coming up (Twins, White Sox), so that could be a deciding factor.