Useful stuff in here for the planned trip I'm taking there.
Did a lot of research on hotels, Hally also recommended the Constanza as well as the Turin, plus gave a lot of great info on which areas are good, which to avoid.
Ended up plumping for the Torre Catalunya - slightly out of the centre but by a massive plaza. Excellent trip advisor reviews, check out what they call "Attic Rooms". Bit pricey but I aint paying. Budget versions exist of course, e.g. Expo opposite with a cool pool on the roof, but since I'm going there on business I reasoned that a hotel with excellent review re comfort and quietness were a must. No hotels with thin walls for me and deffo not in the more lively parts of town.
Really dig deep into (more recent) reviews on trip advisor - things aren't always what they seem with city hotels. Visitor photos, for example, show up a lot more than the so-called professional ones.
Oh and there's a big exposition there (the one I am going to) on June 13th & 14th, so quite a few of the 'decent' hotels south of the Uni along the Gran Via are already booked up or only have the expensive rooms left.
There's quite a lot of apartments for rent, an option worth checking out, esp since you're going with the missus. I'm going with a colleague (female) so I thought perhaps the apartment option wasn't really viable. Might be perfect for you.
When you going?