With Vidic and Ferdinand out, I would say this is a great chance to get 3 points; we just have to neutralise Nani and win the midfield battle.
If United lose the midfield battle, they usually have their brilliant defence and clinical strikeforce to rely on, however without Valencia and neutralising Nani their strikeforce would be limited, and without Vidic and Ferdinand, their defence can look shaky.
Meireles, Gerrard and Lucas all in midfield for me, without two wide men to help the LB and RB as Lucas can cover and 4-5-1 would be too defensive.
Don't know who to play up front, as it looks unlikely that Carroll will be fit.
Reina
Johnson - Carra - Agger - Aurelio
Gerrard - Lucas - Meireles
Suarez Cole
Kuyt
Im not 100% on who is out and who is in, so please correct me if there is a definite absentee on my chosen XI.