I've only seen the first episode, but so far, it's so different that I wouldn't actually call it a superhero show at all. It feels as much like a superhero show as say, Watchmen feels like a superhero comic.
I understand the links to the broader X-Men/Marvel universe/universes are scant so far, and it's probably best kept that way. The fewer connections, the more freedom they have do what they like with it.