Really want to beat these but Palace away four days later makes a few changes necessary IMO.
With Henderson out, I'd be dropping Can into the "number six" role to see if he's up to speed in that role. I'm not too keen on the idea of Lucas there against Spurs as I think we need mobility against Spurs' high press.
As much as the thought of watching Moreno play 90 minutes pains me, I'd be resting Milner as I see him crucial to our title hopes now and I think he's put in a tremendous amount of effort the last couple of games.
Not sure I'd be starting Firmino or Coutinho either given their recent travels. We can't afford to burn them out but they could be big from the bench.
And does Mignolet now become our cup goalkeeper? I'm not sure I see the point; sink or swim, we need to see how Karius fares against high-class opposition.
Karius
Clyne Matip Lovren Moreno
Can
Lallana Wijnaldum
Mane Sturridge Origi
Subs: Mignolet, Lucas, TAA, Grujic, Coutinho, Firmino, Ings