At minimum I'd like to see three from Saturday keep their place - probably Matip, Can and Mane. Then start Migs, Klavan, Moreno, Wijnaldum, Sturridge, Origi all of whom I'd consider members of the core first 18 (with Gini part of our best XI). That leaves space for just two of the U23's to start - I'd go TAA and then probably Grujic, although it wouldn't surprise me if Stewart got a start too.
Which would leave Ings on the bench. Would be disappointing for him, but I think Sturridge and Origi should both start and doubt we'll play with three strikers. Sub him for Sturridge on 60 mins.