I'd go diamond.
To suit Sturridge and a lot of our other players. We don't have a wide player, who can offer what Mane does. So instead of playing someone out of position, like Lallana on the weekend or Sturridge, Firmino & Origi in the past matches. Play to our strengths, we have three very good strikers, who are best central, with freedom to drift wide - play a system to suit them.
We could go 4-2-2-2, with Coutinho and Lallana, playing wide in a 4-4-2 when we don't have the ball. But can roam when we have it. That's another option.
But I'd go with a diamond. Put Coutinho behind Sturridge and Firmino. Lallana, Wijnaldum and Henderson in the other three midfield positions.
Let Sturridge roam, let him focus on winning us the game with his quality, that we all know he has. So many of his best performances for us came in this formation, with and since Suarez has left.
Plan B, if everything is getting narrow and not working, for me is Ojo. Then switch to 4-3-3, Coutinho, Firmino & Ojo in a front three, Lallana in CM with Henderson and Wijnaldum.
I don't want to see Emre Can. He was good against Man U, when we needed his strengths without the ball. Winning headers, pressing, his tackling etc. But in games like this, where we should dominate possession, we need our best players in possession and for me that doesn't include him.
I don't want to see Lallana in the front three. Actually I don't really want to see a front three unless Ojo is in it. For the reasons I gave above, we'll be playing someone out of position otherwise.
Matip obviously should start if available. His composure and ability on the ball to start attacks can make a difference.
The crowd also have a vital part to play. They do every game though.